Hypersensitivity Types Multiple Choice Question And Answer

Question 1. Asthma is due to which type of hypersensitivity reaction?

1. Type 1
2. Type 2
3. Type 3
4. Type 4

Answer. (1) (Type 1)

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Question 2. Schultz-Dale phenomenon, the following is true statement:

1. Anaphylaxis in vitro
2. Test to detect atopy
3. Type V hypersensitivity reaction
4. Test for allergic contact dermatitis

Answer. (1) (Anaphylaxis in vitro )

• Schultz-Dale phenomenon is an example of type I hypersensitivity (Anaphylaxis in vitro)

Question 3. Type I hypersensitivity is mediated by which of the following immunoglobulins?

1. IgA
2. IgG
3. IgM
4. IgE

Answer. (4) (IgE)

• Type 1 hypersensitivity reaction is dependent on IgE antibody (also known as Reagin antibody or cytotropic antibody).

Question 4. Anaphylaxis is mediated by:

1. 5-hydroxytryptamine
2. Heparin
3. Prostaglandin
4. Anaphylotoxins from complement activation
5. Platelet-activating factor

Answer. ALL (1) (2) (3) (4) (5) (5-hydroxytryptamine, Heparin, Prostaglandin, Anaphylotoxins from complement activation, Platelet-activating factor)

Question 5. Allergic rhinitis is an example of: (Recent MC2013)

1. Type I hypersensitivity reaction
2. Type II hypersensitivity reaction
3. Type III hypersensitivity reaction
4. Type IV hypersensitivity reaction

Answer. (1) (Type I hypersensitivity reaction)

• Allergic rhinitis or Hay fever is, e.g. of Type I hypersensitivity reaction.

Question 6. Lysis of red cells in autoimmune anemias and hemolytic disease of the newborn are examples of:

1. Type I hypersensitivity
2. Type II hypersensitivity
3. Type III hypersensitivity
4. Type IV hypersensitivity

Answer. (2) (Type II hypersensitivity)

Question 7. Two days after penicillin administration, antibodies developed that resulted in hemolysis. Which type of hypersensitivity reaction is this?

1. Type-I
2. Type-II
3. Type-III
4. Type-IV

Answer. (2) (Type-II)

Penicillin in high doses can induce immune-mediated hemolysis via the hapten mechanism in which antibodies are targeted against the combination of penicillin in association with red blood cells. Complement is activated by the attached antibody leading to the removal of red blood cells by the spleen. This is an example of drug-induced type-II hypersensitivity reaction.

Question 8. Serum sickness is which type of reaction?

1. Type 1
2. Type 2
3. Type 3
4. Type 4

Answer. (3) (Type 3)

Question 9. Which of the following is an immune complex-mediated disease?

1. SLE
2. Bronchial asthma
3. Rheumatoid arthritis
4. Goodpasture
5. Tuberculin skin test

Answer. (1, 3) (SLE, RA)

• SLE and Rheumatoid arthritis – Type III (Immune complex mediated hypersensitivity)
• Bronchial asthma (HSN type I), Good pasture (HSN type II) and Tuberculin test (HSN type IV)
• Rheumatoid arthritis, there is complex of both type III and IV hypersensitivity Reaction.
  But Type III is a more appropriate answer than type IV.

Question 10. Type II lepra reaction is an example hypersensitivity type:

1. I
2. II
3. III
4. IV

Answer. (3) (III)

Question 11. The hypersensitivity reaction involved in the hyperacute rejection of renal transplant is:

1. Type I
2. Type II
3. Type III
4. Type IV

Answer. (3) (Type III)

• Hyperacute graft rejection is an examples of Types III Hypersensitivity reaction whereas chronic graft rejection and Graft-versus-host disease is Types IV Hypersensitivity reaction.

Question 12. Which of the following is type IV hypersensitivity reaction?

1. Arthus reaction
2. Serum sickness
3. Schwartzman reaction
4. Granulomatous disease

Answer. (4) (Granulomatous disease)

• Granulomatous disease– type IV Hypersensitivity reaction
• Arthus reaction, Serum sickness and Schwartzman reaction – type III Hypersensitivity reaction.

Question 13. Skin tests are used for which hypersensitivity reactions?

1. I
2. II
3. II
4. IV
5. V

Answer. (1, 4) (Type I, IV)

• Type I skin test: Casoni skin test
• Type IV skin test: Tuberculin, Lepromin and patch test.