General Properties Of Viruses
Question 1. IFN beta stimulated by:
- Bacterial infection
- Viral infection
- Fungal infection
- Mycoplasma infection
Answer. (2) (Viral infection)
- IFN-α and IFN-β are induced by viruses. In general, RNA viruses and avirulent viruses are stronger inducers of IFNs than DNA viruses or virulent viruses
- IFN-γ production is not induced by viruses; it is induced by mitogen or antigen contact, usually from intracellular organisms.
Read And Learn More: Micro Biology And Immunology Multiple Choice Question And Answers
Question 2. Which one of the following vaccines is contraindicated in children with egg allergy?
- MMR
- BCG
- DPT
- Yellow Fever
Answer. (4) (Yellow Fever)
- Vaccines prepared in embryonated egg (e.g. yellow fever-17D, Rabies-Flury, and Influenza vaccines) are contraindicated in persons having egg allergy.
Question 3. Which of the following is an example of an RNA oncogenic virus?
- Retroviruses
- Reoviruses
- Coronaviruses
- Arboviruses
Answer. (1) (Retroviruses)
- Oncogenic RNA viruses-HTLV1 (Retroviruses) and HCV.
Question 4. Virus quantification is done by: (NEET Pattern Based)
- Egg inoculation
- Hemadsorption
- Plaque assay
- Electron microscopy
Answer. (3) (Plaque assay)
- Assay of infectivity of viruses:
- Quantal assay: Endpoint biologic assays
- Quantitative infectivity assay: Plaque assay and Pock assay
Question 5. Brick-shaped virus:
- Chickenpox
- Smallpox
- CMV
- EBV
Answer. (2) (Small…)
- Most of the viruses are roughly spherical except
- Rabies: Bullet-shaped, Pox virus- Brick shaped, Tobacco mosaic virus– Rod-shaped
- Adenovirus: Space vehicle shaped, Ebola virus- Filamentous shaped
Question 6. Suckling mice are used for the isolation of:
- Coxsackie virus
- Herpes
- Pox
- Adenovirus
Answer. (1) (Coxsackie virus)
- Suckling mice are used for the isolation of Coxsackie and Arbovirus
Question 7. The human fibroblast cell line is used for the cultivation of:
- Adenovirus
- Poliovirus
- CMV
- Measles
Answer. (3) (CMV)
The human fibroblast cell line is used for the cultivation of CMV
Question 8. Both intranuclear and cytoplasmic inclusion is seen in:
- Poxvirus
- Herpesvirus
- Measles virus
- Mumps virus
Answer. (3) (Measles virus)
- Both intranuclear and cytoplasmic inclusion are seen in:- Measles and CMV
Question 9. True about interferon is:
- Host protein
- Viral protein
- Inactivated by nucleases
- Virus-specific
Answer. (1) (Host protein)
- Interferons are Host-specific proteins, not virus-specific.
- Interferons are inactivated by proteolytic enzymes but resistant to nucleases and lipases.
Question 10. Which of the following is the primary cell line?
- Chick embryo fibroblast
- HeLa cells
- Vero cells
- WI-38
Answer. (1) (Chick embryo fibroblast)
- Examples of primary cell lines: Rhesus Kidney cell line, Human amniotic cell line, Chick embryo fibroblast
Question 11. Continuous cell line for viruses not present for:
- Vero
- Hep2
- WI-38
- Hela
Answer. (3) (WI-38)
- WI-38: Human embryonic lung cell strain is an example of a Secondary cell line.
Question 12. Viral inclusion bodies are all except:
- Psamomma bodies
- Molluscum
- Negri
- Bollinger
Answer. (1) (Psamomma bodies)
- Psammoma bodies (PBs) are concentric lamellated calcified structures, observed most commonly in papillary thyroid carcinoma (PTC), meningioma, and papillary serous cystadenocarcinoma of the ovary.
- Other options are examples of viral inclusion bodies seen in:
- Molluscum body (Molluscum contagiosum virus)
- Negri body (Rabies)
- Bollinger body (Fowlpox)
Question 13. Viral infections that are least transmitted transplacentally are:
- Hepatitis B
- Rubella
- Herpes simplex
- HIV
Answer. (1) (Hepatitis B)
- Rubella and HSV are teratogenic viruses, so their transplacental transmission is expected to be high
- HIV has an overall transplacental transmission of 30%
- HBV can also be transmitted transplacentally, but among the options, HBV has the least chance of transplacental transmission.
- List of teratogenic viruses—refer to chapter review.
- List of viruses that transfer through the Placenta.
Question 14. Latency seen in viral infections:
- HSV–II
- CMV
- Rotavirus
- HIV
- EBV
Answer. (1, 2, 4, 5) (HSV-2, CMV, HIV, EBV) Persistent Infections are characterized as those in which the virus is not cleared but remains in specific cells of infected individuals.
Responsible for 20% of human cancers. It is of 3 overlapping varieties.
1. Latent infection: Defined as a state of infection in which the virus is not replicating i.e. any demonstrable infectious virus between episodes of recurrent disease.
2. Chronic infection: Characterized by the continued presence of infectious virus following the primary infection. For example, HBV, HCV
3. Slow infection: Characterized by a prolonged incubation period followed by progressive disease. Without any acute period of viral multiplication.
Question 15. Which of the following is not an RNA virus?
- Ebola
- Simian 40
- Rabies
- Vesicular stomatitis virus
Answer. (2) (Simian 40)
- Simian Vacuolating virus (SV40) is an example of Papillomavirus (DNA virus) affecting monkeys. Ananthanarayan 9/e p552, 10/e p434
- Vesicular stomatitis virus and Rabies are examples of Rhabdovirus (RNA virus) Ebola virus belongs to Filoviridae (RNA Virus)
Question 16. Both DNA and RNA are found in:
- All Bacteria
- Prion
- Viroid
- Plasmid
Answer. (1) (All Bacteria)
Question 17. All the following vaccines are developed from embryonated eggs except:
- Influenza
- Hepatitis-A
- Yellow fever
- Rabies
- CMV
Answer. (2, 5) (Hepatitis-A, CMV)
- The vaccines prepared in embryonated eggs are the influenza vaccine, Rabies (Flury vaccine), and Yellow fever 17 D vaccine.
- Site of inoculation in the egg for all the above vaccine production- Allanotic sac.
Question 18. The following is not a live vaccine:
- Measles
- BCG
- Yellow fever
- Salk’s vaccine
Answer. (4) (Salk’s vaccine)
Question 19. True about interferon:
- Viral protein
- Virus-specific
- Host protein
- Inactivated by nucleases
Answer. (3) (Host protein)
Question 20. Interferon-gamma secreted by:
- Activated T-cell
- CD 8 cells
- RBC
- Neutrophils
Answer. (1) (Activated T-cell)
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