General Properties Of Viruses Multiple Choice Question an Answers

General Properties Of Viruses

Question 1. IFN beta stimulated by:

1. Bacterial infection
2. Viral infection
3. Fungal infection
4. Mycoplasma infection

Answer. (2) (Viral infection)

• IFN-α and IFN-β are induced by viruses. In general, RNA viruses and avirulent viruses are stronger inducers of IFNs than DNA viruses or virulent viruses
• IFN-γ production is not induced by viruses; it is induced by mitogen or antigen contact, usually from intracellular organisms.

Read And Learn More: Micro Biology And Immunology Multiple Choice Question And Answers

Question 2. Which one of the following vaccines is contraindicated in children with egg allergy?

1. MMR
2. BCG
3. DPT
4. Yellow Fever

Answer. (4) (Yellow Fever)

• Vaccines prepared in embryonated egg (e.g. yellow fever-17D, Rabies-Flury, and Influenza vaccines) are contraindicated in persons having egg allergy.

Question 3. Which of the following is an example of an RNA oncogenic virus?

1. Retroviruses
2. Reoviruses
3. Coronaviruses
4. Arboviruses

Answer. (1) (Retroviruses)

• Oncogenic RNA viruses-HTLV1 (Retroviruses) and HCV.

Question 4. Virus quantification is done by: (NEET Pattern Based)

1. Egg inoculation
2. Hemadsorption
3. Plaque assay
4. Electron microscopy

Answer. (3) (Plaque assay)

• Assay of infectivity of viruses:
• Quantal assay: Endpoint biologic assays
• Quantitative infectivity assay: Plaque assay and Pock assay

Question 5. Brick-shaped virus:

1. Chickenpox
2. Smallpox
3. CMV
4. EBV

Answer. (2) (Small…)

• Most of the viruses are roughly spherical except
• Rabies: Bullet-shaped, Pox virus- Brick shaped, Tobacco mosaic virus– Rod-shaped
• Adenovirus: Space vehicle shaped, Ebola virus- Filamentous shaped

Question 6. Suckling mice are used for the isolation of:

1. Coxsackie virus
2. Herpes
3. Pox
4. Adenovirus

Answer. (1) (Coxsackie virus)

• Suckling mice are used for the isolation of Coxsackie and Arbovirus

Question 7. The human fibroblast cell line is used for the cultivation of:

1. Adenovirus
2. Poliovirus
3. CMV
4. Measles

Answer. (3) (CMV)

The human fibroblast cell line is used for the cultivation of CMV

Question 8. Both intranuclear and cytoplasmic inclusion is seen in:

1. Poxvirus
2. Herpesvirus
3. Measles virus
4. Mumps virus

Answer. (3) (Measles virus)

• Both intranuclear and cytoplasmic inclusion are seen in:- Measles and CMV

Question 9. True about interferon is:

1. Host protein
2. Viral protein
3. Inactivated by nucleases
4. Virus-specific

Answer. (1) (Host protein)

• Interferons are Host-specific proteins, not virus-specific.
• Interferons are inactivated by proteolytic enzymes but resistant to nucleases and lipases.

Question 10. Which of the following is the primary cell line?

1. Chick embryo fibroblast
2. HeLa cells
3. Vero cells
4. WI-38

Answer. (1) (Chick embryo fibroblast)

• Examples of primary cell lines: Rhesus Kidney cell line, Human amniotic cell line, Chick embryo fibroblast

Question 11. Continuous cell line for viruses not present for:

1. Vero
2. Hep2
3. WI-38
4. Hela

Answer. (3) (WI-38)

• WI-38: Human embryonic lung cell strain is an example of a Secondary cell line.

Question 12. Viral inclusion bodies are all except:

1. Psamomma bodies
2. Molluscum
3. Negri
4. Bollinger

Answer. (1) (Psamomma bodies)

• Psammoma bodies (PBs) are concentric lamellated calcified structures, observed most commonly in papillary thyroid carcinoma (PTC), meningioma, and papillary serous cystadenocarcinoma of the ovary.
• Other options are examples of viral inclusion bodies seen in:
• Molluscum body (Molluscum contagiosum virus)
• Negri body (Rabies)
• Bollinger body (Fowlpox)

Question 13. Viral infections that are least transmitted transplacentally are:

1. Hepatitis B
2. Rubella
3. Herpes simplex
4. HIV

Answer. (1) (Hepatitis B)

• Rubella and HSV are teratogenic viruses, so their transplacental transmission is expected to be high
• HIV has an overall transplacental transmission of 30%
• HBV can also be transmitted transplacentally, but among the options, HBV has the least chance of transplacental transmission.
• List of teratogenic viruses—refer to chapter review.
• List of viruses that transfer through the Placenta.

Question 14. Latency seen in viral infections:

1. HSV–II
2. CMV
3. Rotavirus
4. HIV
5. EBV

Answer. (1, 2, 4, 5) (HSV-2, CMV, HIV, EBV) Persistent Infections are characterized as those in which the virus is not cleared but remains in specific cells of infected individuals.

Responsible for 20% of human cancers. It is of 3 overlapping varieties.

1. Latent infection: Defined as a state of infection in which the virus is not replicating i.e. any demonstrable infectious virus between episodes of recurrent disease.
2. Chronic infection: Characterized by the continued presence of infectious virus following the primary infection. For example, HBV, HCV
3. Slow infection: Characterized by a prolonged incubation period followed by progressive disease. Without any acute period of viral multiplication.

Question 15. Which of the following is not an RNA virus?

1. Ebola
2. Simian 40
3. Rabies
4. Vesicular stomatitis virus

Answer. (2) (Simian 40)

• Simian Vacuolating virus (SV40) is an example of Papillomavirus (DNA virus) affecting monkeys. Ananthanarayan 9/e p552, 10/e p434
• Vesicular stomatitis virus and Rabies are examples of Rhabdovirus (RNA virus) Ebola virus belongs to Filoviridae (RNA Virus)

Question 16. Both DNA and RNA are found in:

1. All Bacteria
2. Prion
3. Viroid
4. Plasmid

Answer. (1) (All Bacteria)

Question 17. All the following vaccines are developed from embryonated eggs except:

1. Influenza
2. Hepatitis-A
3. Yellow fever
4. Rabies
5. CMV

Answer. (2, 5) (Hepatitis-A, CMV)

• The vaccines prepared in embryonated eggs are the influenza vaccine, Rabies (Flury vaccine), and Yellow fever 17 D vaccine.
• Site of inoculation in the egg for all the above vaccine production- Allanotic sac.

Question 18. The following is not a live vaccine:

1. Measles
2. BCG
3. Yellow fever
4. Salk’s vaccine

Answer. (4) (Salk’s vaccine)

Question 19. True about interferon:

1. Viral protein
2. Virus-specific
3. Host protein
4. Inactivated by nucleases

Answer. (3) (Host protein)

Question 20. Interferon-gamma secreted by:

1. Activated T-cell
2. CD 8 cells
3. RBC
4. Neutrophils

Answer. (1) (Activated T-cell)